Skin Quality Enhancement Injectables in London
Glowing, healthy skin is the foundation of a refreshed appearance. Our skin quality enhancement injectables, including Polynucleotides and Profhilo, work from within to rebuild collagen, deepen hydration and restore firmness, visibly improving the texture and tone of your skin without adding volume.
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Skin Quality Injectables Overview
Skin quality enhancement injectables are a category of regenerative treatments designed to improve the underlying health, structure and resilience of your skin rather than altering its shape. Unlike traditional fillers that add volume, these biostimulators work with your skin's biology to rebuild collagen, restore hydration and improve elasticity from within.
At The Ghanem Clinic, we offer two leading skin quality treatments, Polynucleotides and Profhilo, both delivered by experienced medical practitioners following a personalised consultation. The result is firmer, more luminous skin that looks healthier, not "done".
Choosing Skin Quality Injectables
These treatments suit patients noticing fine lines, dullness, dehydration, loss of elasticity, or early signs of crepiness in delicate areas like the neck, under-eyes and décolletage. They are also widely chosen as preparation ahead of laser resurfacing or other aesthetic procedures, and pair well with anti-wrinkle injections for a fully refined result.
Skin Quality Injectables vs. Dermal Fillers
The two categories are often confused but do very different things. Dermal fillers add volume to restore contour and structure. Skin quality injectables remodel the skin itself, improving hydration, firmness and texture without changing facial shape. Many patients use both in combination for a result that addresses both volume loss and skin quality.
Polynucleotides & Profhilo
Two of the most respected regenerative injectables in modern aesthetic medicine, each chosen for specific skin concerns and stage of ageing.
| Polynucleotides | Profhilo | |
|---|---|---|
| Best For | Damaged, tired or scarred skin | Dehydrated, crepey or lax skin |
| How It Works | DNA-derived molecules activate cellular regeneration | Stabilised hyaluronic acid remodels skin from within |
| Treatment Time | 20–40 minutes | 15–30 minutes |
| Protocol | Course of sessions, intervals tailored to skin | 2 sessions, 1 month apart |
| Optimal Results | 6–8 weeks after first session | Up to 8 weeks after second session |
| Maintenance | 6–12 months | Every 6–9 months |
Polynucleotide Rejuvenation
What It Treats
Polynucleotide injections are ideal for skin showing signs of fatigue, dehydration or early ageing, including fine lines, dullness, loss of elasticity, and scarring. The treatment is particularly effective for:
- Smoothing shallow wrinkles
- Improving skin quality and hydration
- Reducing the appearance of scarring
- Enhancing delicate areas like the neck, décolletage and under-eyes
- Preparing the skin for lasers or other aesthetic procedures
How It Works
Polynucleotides are naturally derived molecules found in DNA that support cell regeneration and skin repair. Injected into the skin, they activate fibroblasts and stem cells to boost collagen production, deeply hydrate, and neutralise free radicals, restoring elasticity, brightness, and skin health over time.
The Treatment
After assessing your skin, your practitioner selects the appropriate formulation (PDRN Medium or Strong). The skin is cleansed and a topical numbing cream may be applied. Using either microinjections or a cannula, the polynucleotide solution is gently administered into targeted areas. The procedure typically lasts 20–40 minutes and is well tolerated with minimal discomfort. Mild redness or swelling may occur but usually fades within hours.
Results
Initial improvements in hydration and texture may be visible shortly after treatment. The real transformation unfolds over several weeks as new collagen forms and cellular repair is activated, with optimal results appearing 6–8 weeks after your first session. A course of treatments is often recommended for cumulative, longer-lasting benefits.
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Profhilo Skin Remodelling
What It Treats
Profhilo is ideal for skin that feels dull, crepey, tired or dehydrated, with visible loss of firmness or elasticity. It is particularly well suited to delicate or hard-to-treat areas where traditional fillers are less appropriate, including:
- The neck and jawline
- The hands
- The forehead
- The décolletage
- The face for an overall radiance boost
How It Works
Profhilo is a next-generation injectable that works differently from traditional fillers. It contains a highly concentrated, stabilised form of hyaluronic acid that spreads smoothly beneath the skin, attracting water and stimulating the production of four types of collagen and elastin. Rather than volumising, it remodels and improves skin quality, enhancing hydration, tone, elasticity and firmness from within.
The Treatment
Profhilo is administered via small injections into five strategic Bio-Aesthetic Points (BAPs) on each side of the face, carefully selected for optimal diffusion and natural-looking results. The treatment takes 15–30 minutes. A numbing cream may be applied beforehand, but discomfort is minimal. Most patients resume normal activities shortly after.
Results
Many patients notice improvements in skin texture and hydration within days of the first session. Over the following weeks, collagen and elastin production are stimulated, leading to visibly firmer, smoother and more radiant skin. The recommended protocol is two sessions one month apart, with results continuing to develop for up to 8 weeks. Maintenance treatments every 6–9 months help sustain results.
Book ProfhiloYour Treatment Journey
Initial Consultation
Your journey begins with a private consultation at our Wimpole Street clinic. Your practitioner assesses your skin quality, hydration, elasticity and overall concerns to determine whether Polynucleotides, Profhilo, or a combined approach is right for you.
Personalised Plan
Based on your assessment, a tailored plan is created, identifying the right product, treatment area, number of sessions and intervals between appointments. Any complementary treatments are discussed at this stage.
The Treatment
The skin is cleansed, and a topical numbing cream is applied where required. Your practitioner administers the chosen injectable using a fine needle or cannula, with most sessions completed in 15–40 minutes depending on the treatment.
Aftercare and Review
You receive personalised aftercare guidance to support optimal recovery. Follow-up sessions are scheduled at the right intervals to build cumulative results, with reviews to monitor progress and refine your plan as needed.
What to Expect
Skin quality injectables are designed to deliver real, regenerative change with minimal disruption to daily life.
Preparation
You may be advised to avoid blood-thinning medication, alcohol and intensive exercise for 24 hours before treatment to reduce bruising. Arrive with clean skin and no makeup where possible.
The Treatment
The appointment takes 15–40 minutes. After cleansing and applying a topical anaesthetic, your practitioner delivers the injections. Discomfort is minimal and most patients describe it as a brief pinching sensation.
Recovery and Results
You can return to normal activity immediately. Mild redness, swelling or small bumps at injection sites are common but usually settle within hours. Skin texture improvements appear within days and continue to develop over 6–8 weeks.
Regenerative Injectables, Refined Results
Skin quality injectable treatments at The Ghanem Clinic are led by the medical team, a collective of experienced practitioners trained in advanced regenerative injectable techniques. Every plan is designed around your skin biology, concerns and long-term goals, with the same standard of clinical precision and bespoke care that defines our 360-degree approach to aesthetic medicine.
Frequently Asked Questions
What is the difference between Polynucleotides and Profhilo?
Will skin quality injectables change my appearance?
How long do results last?
Is there any downtime?
Can these treatments be combined with other injectables?
Are skin quality injectables painful?
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Radiant Skin, From Within
Book a private consultation to design a regenerative skin plan tailored to your skin biology, concerns, and long-term goals.
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